1452294-87-9Relevant academic research and scientific papers
Short and stereocontrolled cyclic polyglycerols synthesis using BF 3·OEt2 mediated intramolecular epoxide-opening reaction
Hamada, Masahiro,Kishimoto, Takao,Nakajima, Noriyuki
, p. 1533 - 1539 (2013/08/23)
We developed a new method for the stereocontrolled synthesis of cyclic oligoglycerols. Optically pure solketal and epichlorohydrin were coupled with allyl alcohol under aqueous basic conditions to construct a linear triglycerol skeleton. After subsequent steps, the epoxy alcohol (7) obtained was treated with a catalytic amount of BF3·OEt2 in CH 2Cl2 to produce in a high yield of the desired cyclic triglycerol through a regioselective, intramolecular epoxide ring-opening reaction.
