145238-45-5 Usage
Uses
Used in Pharmaceutical Industry:
(R)-Tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, 99% (R)-Phenyl oxazaborolidine is used as a convenient catalyst for the enantioselective borane reduction of ketones at ambient temperatures. This application is particularly important in the pharmaceutical industry, where the synthesis of chiral drugs with high enantiomeric purity is crucial. The use of (R)-Tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, 99% (R)-Phenyl oxazaborolidine as a catalyst allows for the selective reduction of ketones to form chiral alcohols, which can be further utilized in the development of various pharmaceutical products.
Used in Chemical Synthesis:
In the field of chemical synthesis, (R)-Tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, 99% (R)-Phenyl oxazaborolidine serves as a valuable catalyst for enantioselective borane reduction reactions. This enables chemists to synthesize a wide range of chiral compounds with high enantiomeric purity, which are essential for various applications, including the development of new drugs, agrochemicals, and other specialty chemicals.
Used in Research and Development:
(R)-Tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxaborole, 99% (R)-Phenyl oxazaborolidine is also utilized in research and development laboratories for the study of enantioselective catalysis and the development of new synthetic methods. Its high purity and catalytic efficiency make it an ideal candidate for exploring the potential of enantioselective borane reduction in various chemical transformations, leading to the discovery of novel compounds and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 145238-45-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,2,3 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 145238-45:
(8*1)+(7*4)+(6*5)+(5*2)+(4*3)+(3*8)+(2*4)+(1*5)=125
125 % 10 = 5
So 145238-45-5 is a valid CAS Registry Number.
145238-45-5Relevant academic research and scientific papers
PROCESS TO MAKE A SELECTIVE CATHEPSIN CYSTEINE PROTEASE INHIBITOR
-
Page/Page column 20-21, (2020/02/23)
A method of preparing a compound of Formula (I) comprising reacting the compound of Formula (A) with a base and a compound of Formula (B) to yield a compound of Formula (C).
Modular, Scalable Synthesis of Group A Streptogramin Antibiotics
Li, Qi,Seiple, Ian B.
supporting information, p. 13304 - 13307 (2017/10/05)
Streptogramin antibiotics are used clinically to treat multidrug-resistant bacterial infections, but their poor physicochemical properties and narrow spectra of activity have limited their utility. New methods to chemically modify streptogramins would enable structural optimization to overcome these limitations as well as to combat growing resistance to the class. Here we report a modular, scalable synthesis of group A streptogramin antibiotics that proceeds in 6-8 linear steps from simple chemical building blocks. We have applied our route to the synthesis of four natural products in this class including two that have never before been accessed by fully synthetic routes. We anticipate that this work will lead to the discovery of new streptogramin antibiotics that overcome previous limitations of the class.
