1452392-31-2Relevant academic research and scientific papers
Highly efficient enantioselective construction of bispirooxindoles containing three stereocenters through an organocatalytic cascade michael-cyclization reaction
Wu, Hao,Zhang, Li-Li,Tian, Zhi-Qing,Huang, Yao-Dong,Wang, Yong-Mei
supporting information, p. 1747 - 1753 (2013/02/25)
Bispirooxindole derivatives containing three stereocenters, including two spiro quaternary centers, were synthesized in a high-yielding, atypically rapid, and stereocontrolled cascade Michael-cyclization reaction between methyleneindolinones and isothiocyanato oxindoles catalyzed by a bi- or multifunctional organocatalyst. Mild conditions were used to construct bispirooxindoles with excellent enantio- and diastereomeric purities within less than 1 min. Catalyst reconfiguration offered access to the opposite enantiomer. This exceptionally highly efficient procedure will allow diversity-oriented syntheses of this intriguing class of compounds with potential biological activities. Copyright
