1452394-52-3Relevant academic research and scientific papers
Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies
Bryan, Marian C.,Hein, Christopher D.,Gao, Hua,Xia, Xiaoyang,Eastwood, Heather,Bruenner, Bernd A.,Louie, Steven W.,Doherty, Elizabeth M.
, p. 503 - 511 (2013/09/24)
A platform that incorporates computational library design, parallel solution-phase synthesis, continuous flow hydrogenation, and automated high throughput purification and reformatting technologies was applied to the production of a 120-member library of 1-aryl-4-aminopiperidine analogues for drug discovery screening. The application described herein demonstrates the advantages of computational library design coupled with a flexible, modular approach to library synthesis. The enabling technologies described can be readily adopted by the traditional medicinal chemist without extensive training and lengthy process development times.
