1452406-87-9Relevant academic research and scientific papers
Conformationally assisted lactamizations for the synthesis of symmetrical and unsymmetrical bis-2,5-diketopiperazines
Ha, Khanh,Lebedyeva, Iryna,Li, Zhiliang,Martin, Kristin,Williams, Byron,Faby, Eric,Nasajpour, Amir,Pillai, Girinath G.,Al-Youbi, Abdulrahman O.,Katritzky, Alan R.
, p. 8510 - 8523 (2013/09/24)
Open-chain N-Cbz-protected-peptidoyl benzotriazolides are converted by a novel lactamization strategy using proline as a turn introducer into both symmetrical (5a-c and 11a-c) and unsymmetrical (19a-e) bis-2,5-diketopiperazines (bis-2,5-DKPs), previously recognized as difficult targets.
