145241-75-4 Usage
Uses
Used in Pharmaceutical Industry:
6,8-Difluoroquinoline is used as a precursor in the synthesis of various pharmaceutical compounds for its antimicrobial properties. The presence of fluorine atoms in its structure is believed to enhance its bioavailability and metabolic stability, making it a promising candidate for the development of new drugs to treat bacterial infections.
Used in Antimicrobial Drug Development:
6,8-Difluoroquinoline is utilized as a key component in the creation of antimicrobial agents, targeting a range of bacterial infections. Its unique structure allows for the potential to develop drugs that are more effective against resistant strains of bacteria, offering new treatment options for patients.
Used in Research and Development:
In the field of pharmaceutical research and development, 6,8-difluoroquinoline serves as a valuable compound for exploring its potential applications in medicine. Scientists are investigating its properties to understand how it can be harnessed to create innovative treatments and improve existing therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 145241-75-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,2,4 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 145241-75:
(8*1)+(7*4)+(6*5)+(5*2)+(4*4)+(3*1)+(2*7)+(1*5)=114
114 % 10 = 4
So 145241-75-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H5F2N/c10-7-4-6-2-1-3-12-9(6)8(11)5-7/h1-5H
145241-75-4Relevant academic research and scientific papers
Glycerol and Q-tubes: Green catalyst and technique for synthesis of polyfunctionally substituted heteroaromatics and anilines
AlMarzouq, Douaa Salman,Elnagdi, Noha M. Hilmy
, (2019/05/24)
The role of glycerol as a green bio-based solvent, reactant, and/or a catalyst in the synthesis of novel heterocycles, under pressure, is studied. Synthesis of novel quinolines in good yields using a new modified Skraup synthesis, utilizing glycerol and pressure Q-tubes, is demonstrated. Novel aniline trimers are prepared using glycerol, and substituted anilines under pressure, in acidic medium and water. Glycerol was employed as a catalyst and a green solvent in the synthesis of novel pyridazines 13a-c. The mechanisms of the reactions and the catalytic effect of glycerol in protic and aprotic media are fully discussed. The structures of the synthesized compounds were determined via X-ray crystallography and spectroscopic methods.
Effects of oligofluorine substitution on the mutagenicity of quinoline: A study with twelve fluoroquinoline derivatives
Kato, Taka-Aki,Saeki, Ken-Ichi,Kawazoe, Yutaka,Hakura, Atsushi
, p. 149 - 157 (2007/10/03)
A total of 12 variously fluorinated derivatives of quinoline (Q) were tested for their mutagenicity in Salmonella typhimurium TA100 in the presence of S9 mix to investigate the structure-mutagenicity relationship in oligofluorinated quinolines. Nine of th
