145243-38-5

Basic information

• Product Name: 2-(Benzhydrylidene-amino)-3-(3-chloro-phenyl)-propionic acid methyl ester
• Synonyms: 2-(Benzhydrylidene-amino)-3-(3-chloro-phenyl)-propionic acid methyl ester
• CAS NO: 145243-38-5
• Molecular Weight: 377.87
• Mol File: 145243-38-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(Benzhydrylidene-amino)-3-(3-chloro-phenyl)-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Benzhydrylidene-amino)-3-(3-chloro-phenyl)-propionic acid methyl ester(145243-38-5)
• EPA Substance Registry System: 2-(Benzhydrylidene-amino)-3-(3-chloro-phenyl)-propionic acid methyl ester(145243-38-5)

Safety Data

• Hazardous Substances Data: 145243-38-5(Hazardous Substances Data)

Upstream product

• 81167-39-7 methyl N-(diphenylmethylene)glycinate 
• 620-20-2 1-Chloro-3-chloromethyl-benzene 
• 766-80-3 1-bromomethyl-3-chlorobenzene 

Downstream Products

• 80126-52-9 (R)-2-amino-3-(3-chlorophenyl)propanoic acid 
• 1956-15-6 3-chlorophenylalanine 

Relevant articles and documents

Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities

Protein tyrosine phosphatase 1B is a key factor in the negative regulation of insulin pathway and a promising target for treatment of diabetes and obesity. Herein, a series of competitive inhibitors were optimized from oleanolic acid, a natural triterpenoid identified against PTP1B by screening libraries of traditional Chinese medicinal herbs. Modifying at 3 and 28 positions, we obtained compound 13 with a Ki of 130 nM, which exhibited good selectivity between other phosphatases involved in insulin pathway except T-cell protein tyrosine phosphatase. Further evaluation in cell models illustrated that the derivatives enhanced insulin receptor phosphorylation in CHO/hIR cells and also stimulated glucose uptake in L6 myotubes with or addition of without insulin.