14526-02-4Relevant academic research and scientific papers
Synthesis, characterization, biological screenings and interaction with calf thymus DNA as well as electrochemical studies of adducts formed by azomethine [2-((3,5-dimethylphenylimino)methyl)phenol] and organotin(IV) chlorides
Sirajuddin, Muhammad,Ali, Saqib,Haider, Ali,Shah, Naseer Ali,Shah, Afzal,Khan, Muhammad Rashid
, p. 19 - 31 (2012)
Novel azomethine adducts of Sn(IV) have been synthesized by the reaction of RnSnCl4-n (n = 1-3, R = CH3, n-C4H9, C6H5, C6H 11) with 2-((3,5-dimethylphenylimino)methyl)phenol (HL). The products were characterized by elemental analysis, FT-IR, 1H, 13C and 119Sn NMR spectroscopy. Triphenyltin(IV) chloride [2-((3,5-dimethylphenylimino)methyl)phenol] (3) was also characterized by single crystal analysis. Spectroscopic and crystal data suggest that in all the complexes the ligand acts as a monodentate neutral molecule and is coordinated through oxygen to the tin atom forming pentacoordinated tin species. The phenolic hydrogen within the ligand is transferred to the imine nitrogen atom due to the coordination of oxygen with tin after complex formation. The ligand and its complexes have been screened for their biological activities, including DNA interaction, enzymatic, antibacterial, antifungal and cytotoxicity studies. Moreover, the electrochemical behavior of the synthesized compounds was also studied and the results obtained evidenced their irreversible oxidation.
Reversible-irreversible approach to schiff base macrocycles: Access to isomeric macrocycles with multiple salphen pockets
Frischmann, Peter D.,Jiang, Jian,Hui, Joseph K.-H.,Grzybowski, Joseph J.,MacLachlan, Mark J.
supporting information; body text, p. 1255 - 1258 (2009/04/06)
We have developed methodology for the formation of a new family of metal-free Schiff base macrocycles utilizing the differential exchange rates of aldimines and ketimines. The more robust ketimine bond Is kinetically Inert under the milder conditions used for aldimine bond formation. In particular, this route enables access to the first conjugated macrocycles with four unsymmetrical N2O2 salphen-like pockets.
