145263-72-5

Upstream product

• 149885-09-6 (2S,3S)-3-((R)-1-Benzyloxy-ethyl)-2-methyl-pent-4-ynoic acid 

Downstream Products

• 145100-19-2 5-[(3S,4S)-3-((R)-1-Benzyloxy-ethyl)-4-methyl-5-oxo-pyrrolidin-(2Z)-ylidenemethyl]-3-(2-methoxycarbonyl-ethyl)-4-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 188923-05-9 5-[(3S,4S)-3-((R)-1-Benzyloxy-ethyl)-4-carbamoyl-pent-1-ynyl]-3-(2-methoxycarbonyl-ethyl)-4-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 145100-18-1 5-[(3R,4S)-3-((R)-1-Benzyloxy-ethyl)-4-carbamoyl-pent-1-ynyl]-3-(2-methoxycarbonyl-ethyl)-4-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Dihydropyrromethenones by Pd(0)-Mediated Coupling of Iodopyrroles and Acetylenic Amides. Synthesis of the A,B-Ring Segment of Phytochrome

Dihydropyrromethenone derivative 32b, which constitutes the A,B-ring segment of phytochrome (6), has been prepared in enantiomerically pure form beginning with acetylenic amide 47b and iodopyrrole 27. The key steps involved the TBAF-catalyzed 5-exo-dig cyclization of the acetylenic pyrrole 48b, followed by thia-Mitsunobu inversion of the resulting alcohol derivative 31b.