1452759-73-7

Basic information

• Product Name: (Z)-2-(5-(4-bromo-2-fluorobenzylidene)-2,4-dioxothizolidin-3-yl)acetic acid
• CAS NO: 1452759-73-7
• Molecular Weight: 360.16
• Mol File: 1452759-73-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-2-(5-(4-bromo-2-fluorobenzylidene)-2,4-dioxothizolidin-3-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(5-(4-bromo-2-fluorobenzylidene)-2,4-dioxothizolidin-3-yl)acetic acid(1452759-73-7)
• EPA Substance Registry System: (Z)-2-(5-(4-bromo-2-fluorobenzylidene)-2,4-dioxothizolidin-3-yl)acetic acid(1452759-73-7)

Safety Data

• Hazardous Substances Data: 1452759-73-7(Hazardous Substances Data)

Upstream product

• 18345-22-7 (2,4-dioxothiazolidin-3-yl)acetic acid methyl ester 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 31061-24-2 2-(2,4-dioxo-1,3-thiazolidin-3-yl)acetic acid 

Relevant articles and documents

Synthesis, characterization, and biological evaluation of thiazolidine-2,4-dione derivatives

As a part of our continuation studies in developing new derivatives as dual antimicrobial/antitumor agents we describe the synthesis of new (Z)-2-(5-arylidene-2,4-dioxothiazolidin-3-yl) acetic acid derivatives (3a-m). The chemical structures of the compound were elucidated by FTIR, 1H NMR, 13C NMR, and elemental analysis data. The antimicrobial activity of all products was examined. All newly synthesized compounds were tested for their in vitro anticancer activity against four cancer cell lines. Among the synthesized compounds, 3a exhibited notable activity against HeLa, HT29, A549, and MCF-7 cell lines with IC50 values of 55, 40, 38, and 50 μM, respectively. In order to predict the drug likeliness of the synthesized compounds on the guidelines of Lipinski rule of five studies was carried out using Pallas software.