145276-62-6Relevant academic research and scientific papers
Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives
Gokce, Mehtap,Dogruer, Deniz,Sahin, Mustafa Fethi
, p. 233 - 237 (2001)
A series of 3-pyridazinones carrying morpholino, arylpiperidino and arylpiperazino moiety in the position 6 IIa-g were synthesized and evaluated for antinociceptive activity. In the modified Koster test in mice 4-(4-fluorophenyl) piperazine, IIf, was found the most active compound. All the compounds except IId were more active than aspirin in the antinociceptive activity test.
Synthesis of antipyrine/pyridazinone hybrids and investigation of their in vivo analgesic and anti-inflammatory activities
Baytas, Sultan,Inceler, Nazan,Mavaneh, Khatereh Fattahpour,Uludag, Mecit Orhan,Abacioglu, Nurettin,Goekce, Mehtap
, p. 734 - 748 (2013/02/23)
Eleven antipyrine/pyridazinone hybrids were synthesized and evaluated for their in vivo analgesic and anti-inflammatory activities by p-benzoquinone- induced writhing test and carrageenan-induced paw edema model, respectively. The test results indicated t
Synthesis and pharmacological activity of some new pyridazinones
Corsano, S,Strappaghetti, G,Codagnone, A,Scapicchi, R,Marucci, G
, p. 545 - 549 (2007/10/02)
The synthesis of a series of piperazinyl-pyridazinones is reported. The blocking activity of these compounds was determined on the pre- and postsynaptic α-adrenoreceptors of isolated rat vas deferens. For compounds 7, 17 and 18, the hypotensive activity w
