145276-76-2Relevant academic research and scientific papers
Oxazolo[3,2-a]pyridine. A new structural scaffold for the reversal of multi-drug resistance in Leishmania
Caballero, Esther,Manzano, Jose Ignacio,Puebla, Pilar,Castanys, Santiago,Gamarro, Francisco,San Feliciano, Arturo
, p. 6272 - 6275 (2012/11/06)
Compounds belonging to three different classes of fused heterocyclic systems, structurally related to Calcium-channel blockers of the 1,4-dihydropyridine family, were evaluated in their ability to overcome leishmanial resistance to common drugs in a MDR Leishmania tropica strain. Compounds with the skeletal basis of oxazolo[3,2-a]pyridine displayed significant reversion of resistance to daunomycin and miltefosine, with reversion indexes up to 6.7-fold and 8.7-fold, respectively. Most interestingly, the enantiopure compound 20S attained to revert the resistance to both drugs and fairly more significantly than its enantiomer 20R.
Synthesis and pharmacological activities of some pyridooxazines
Feliciano, A San,Caballero, E,Puebla, P,Pereira, JAP,Gras, J,Valenti, C
, p. 527 - 535 (2007/10/02)
A novel kind of fused heterocyclic compounds, with the pyridooxazine ring have been prepared and tested for their pharmacologic properties.Some of them have shown long-term antihypertensive-bradycardic effects as well as anti-inflammatory, spasmolytic and other effects. pyrido-oxazine / antihypertensive activity / bradycardic activity / anti-inflammatory activity / spasmolytic activity
