1452830-70-4Relevant academic research and scientific papers
Regioselective synthesis of β-Aryl enaminones and 1,4,5-trisubstituted 1,2,3-triazoles from chalcones and benzyl azides
Xie, Yu-Yang,Wang, Ying-Chun,Qu, Hong-En,Tan, Xian-Chun,Wang, Heng-Shan,Pan, Ying-Ming
, p. 3347 - 3355 (2014)
A highly regioselective synthesis of β-aryl enaminones and 1,4,5-trisubstituted 1,2,3-triazoles from chalcones and benzyl azides based on reaction solvent selection is reported. In the presence of a catalytic amount of Ce (OTf)3, reactions of chalcones with benzyl azides in DMF at 100 °C afforded densely substituted Z-β-aryl enaminones in good to excellent yields, whereas treatment of chalcones with benzyl azides in toluene at 100 °C selectively produced 1,4,5-trisubstituted 1,2,3-triazoles in excellent yields.
An Efficient One-Pot Synthesis of 1,2,3-Triazole-Fused Chromenes/Quinolines via Oxidative [3+2] Cycloaddition followed by Reductive Cyclization
Gangaprasad,Raj, J. Paul,Karthikeyan,Rengasamy,Elangovan
supporting information, p. 4485 - 4490 (2018/10/26)
A convenient and efficient one-pot synthesis of 1,2,3-triazole-fused chromenes/ quinolines is developed. The methodology is based on oxidative azide-olefin [3+2] cycloaddition followed by intramolecular reductive cyclization. This methodology affords fast and simple access to 1,2,3-triazole-fused heterocycles in good to excellent yields without necessitating chromatographic purification. (Figure presented.).
A strategy to access fused triazoloquinoline and related nucleoside analogues
Upadhyaya, Kapil,Ajay, Arya,Mahar, Rohit,Pandey, Renu,Kumar, Brijesh,Shukla, Sanjeev K.,Tripathi, Rama Pati
, p. 8547 - 8558 (2013/09/12)
Fused triazoloquinolines have been prepared starting from (E)-3-(2-nitrophenyl)-1-aryl-prop-2-en-1-ones and sugar or benzyl azides in a sequential [3+2] cycloaddition reaction, followed by one pot Pd-C assisted reduction, cyclization and aromatization. The triazolyl fused quinolines with N1-glycosyl substituents as unnatural nucleosides have inherent potential to generate a library of compounds for bioevaluations.
