145290-29-5Relevant academic research and scientific papers
Stereocontrolled C(sp3)-P bond formation with non-activated alkyl halides and tosylates
Yang, Chu-Ting,Han, Jun,Liu, Jun,Li, Yi,Zhang, Fan,Gu, Mei,Hu, Sheng,Wang, Xiaolin
, p. 24652 - 24656 (2017)
The C(sp3)-P bond is formed via the reaction between P-H compounds and non-activated alkyl electrophiles, especially secondary alkyl halides and tosylates. This reaction proceeds via an SN2 mechanism with inversion of configuration, so it can be used to form C-P bonds with stereocontrol from chiral secondary alcohols.
ALKYLATION REACTIONS OF DIALKYL HYDROGEN PHOSPHITES AND DIARYLPHOSPHINE OXIDES UNDER PHASE-TRANSFER CONDITIONS
Petrov, K. A.,Sivova, L. I.,Smirnov, I. V.,Kryukova, L. Yu.
, p. 264 - 268 (2007/10/02)
It was shown that phosphonates and tertiary phosphine oxides can be synthesized by the alkylation of acid phosphites and diarylphosphine oxides in a nonpolar solvent in presence of solid potassium hydroxide and potassium carbonate and also catalytic amounts of 18-crown ether (or in its absence). (Diarylphosphinyl)methyl ethers of mono- and oligo-etylene glycols were synthesized by the reactions of diaryl(chloromethyl)phosphine oxides with lithium glycolates
