145297-98-9Relevant academic research and scientific papers
High-temperature synthesis of amides from alcohols or aldehydes by using flow chemistry
Ambreen, Nida,Wirth, Thomas
, p. 7590 - 7593 (2014)
An efficient conversion of aliphatic and aromatic alcohols or aldehydes into the corresponding primary amides was successfully achieved by using flow chemistry. Excellent yields were obtained in very short reaction times, and thus this method offers an efficient alternative to traditional methods for amide formation.
Compounds for diagnosis, treatment and prevention of bone injury and metabolic disorders
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Page/Page column 13, (2010/02/12)
The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof useful for the prophylaxis and treatment of degenerative bone disorders and for the acceleration of bone healing.
UNEXPECTED HYDROLYSIS OF 5-AMINOISOXAZOLBENZOYLAMIDE HERBICIDE ISOXABEN INTO 5-ISOXAZOLINONE
Rouchaud, J.,Gustin, F.,Moulard, C.,Plisnier, M.
, p. 557 - 564 (2007/10/02)
The benzoylamide derivative of 5-aminoisoxazol, i.e. the herbicide isoxaben 1 (N--2,6-dimethoxybenzamide) was transformed by aqueous acid hydrolysis into the unexpected 5-isoxazolinone 3 (3-(1-ethyl-1-methylpropyl)isoxazolin 5-one) plus mainly 2,6-dimethoxybenzamide 4.The expected 5-aminoisoxazol 7 (5-amino-3-(1-ethyl-1-methylpropyl)isoxazol) was not generated, except in very low amounts when high acid concentrations were used.In separate hydrolysis trials made in similar aqueous acid conditions, it was observed that the 5-aminoisoxazol 7 and 5-isoxazolinone 3 were not transformed.The 5-isoxazolinone 3 formed by isoxaben 1 acid hydrolysis thus was the first generated product, and was not formed by the consecutive nucleophilic substitution of 5-aminoisoxazol 7 which would have been formed in a first step.This unexpected 5-amino C-N bond cleavage by nucleophilic attack of H2O at the 5-C of the isoxazol ring of isoxaben 1 -instead of the usual amide CO-N bond cleavage- probably is due to the positive charge existing at the 5-C atom of the isoxazol ring.The acid hydrolysis pathway observed for isoxaben 1 also is the main soil metabolism pathway.The absence of formation of an aromatic amino compound by chemical hydrolysis reduces the concern as to their potential transformation into carcinogenic nitroso or azo compounds in soil.On the other hand, isoxaben 1 was not hydrolyzed in aqueous dilute alkali.
