145299-84-9

Basic information

• Product Name: 1,1-difluoro-4-phenyl-butan-2-one
• Synonyms: 1,1-difluoro-4-phenyl-butan-2-one
• CAS NO: 145299-84-9
• Molecular Weight: 184.186
• Mol File: 145299-84-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,1-difluoro-4-phenyl-butan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-difluoro-4-phenyl-butan-2-one(145299-84-9)
• EPA Substance Registry System: 1,1-difluoro-4-phenyl-butan-2-one(145299-84-9)

Safety Data

• Hazardous Substances Data: 145299-84-9(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Slightly sweet and fruity

Applications

a. Synthesis of pharmaceuticals
b. Synthesis of agrochemicals
c. Building block in organic chemistry
d. Flavoring agent in the food industry

Health hazards

a. Eye irritation
b. Skin irritation
c. Respiratory system irritation

Safety concerns

Flammability

Handling precautions

Handle with care due to potential health hazards and flammability

Upstream product

• 102-92-1 Cinnamoyl chloride 
• 80783-99-9 N-methoxy-N-methylcinnamamide 
• 65864-64-4 trimethyl(difluoromethyl)silane 
• 170646-96-5 N-methoxy-N-methyl-3-phenylpropionamide 
• 1338328-42-9 4,4,6,6,6-pentafluoro-5,5-dihydroxy-1-phenylhexan-3-one 
• 454-31-9 ethyl difluoroacetate 
• 103-63-9 1-phenyl-2-bromoethane 
• 645-45-4 hydrocinnamic acid chloride 
• 3277-89-2 phenethylmagnesium bromide 

Downstream Products

• 1541177-55-2 1,1-difluoro-4-phenyl-2-((trimethylsilyl)methyl)butan-2-ol 
• 123986-77-6 (R)-1,1-Difluoro-4-phenyl-butan-2-ol 
• 123986-77-6 (S)-1,1-Difluoro-4-phenyl-butan-2-ol 
• 119454-43-2 Acetic acid 1-difluoromethyl-3-phenyl-propyl ester 
• 123986-77-6 1,1-difluoro-4-phenylbutan-2-ol 

Relevant articles and documents

Synthesis of Difluoromethyl Ketones from Weinreb Amides, and Tandem Addition/Cyclization of o-Alkynylaryl Weinreb Amides

[Difluoro(phenylsulfanyl)methyl]trimethylsilane (PhSCF2SiMe3) underwent a fluoride-induced nucleophilic addition to the carbonyl group of Weinreb amides to provide the corresponding difluoro(phenylsulfanyl)methyl ketones. These were

Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2-Containing Trisubstituted Cyclopropanes

The difluoromethyl (CHF2) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Herein, we report an efficient biocat

Synthesis of Perfluoroalkyl-Substituted Vinylcyclopropanes by Way of Enhanced Neighboring Group Participation

A simple, high yielding, two-step, one-pot protocol for the preparation of trifluoromethyl-substituted vinylcyclopropanes from α-CF3 homoallyl alcohols is disclosed. Destabilization of the cationic intermediate by the electron-withdrawing CF3 group greatly enhances neighboring group participation of the alkene, allowing ring closure to predominate. The reaction can be extended to the difluoromethyl and pentafluoroethyl group, enabling the preparation of a diverse array of fluoroalkyl-substituted vinylcyclopropanes. A diverse array of fluoroalkyl-substituted vinylcyclopropanes are prepared in a simple, high-yielding, two-step, one-pot protocol by means of cationic ring-closure.