1453-59-4

Basic information

• Product Name: β-hydroxy-acetylfentanyl
• Synonyms: β-hydroxy-acetylfentanyl
• CAS NO: 1453-59-4
• Molecular Weight: 338.45
• Mol File: 1453-59-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: β-hydroxy-acetylfentanyl(CAS DataBase Reference)
• NIST Chemistry Reference: β-hydroxy-acetylfentanyl(1453-59-4)
• EPA Substance Registry System: β-hydroxy-acetylfentanyl(1453-59-4)

Safety Data

• Hazardous Substances Data: 1453-59-4(Hazardous Substances Data)

Upstream product

• 22352-82-5 N-phenyl-N-(piperidin-4-yl)acetamide hydrochloride 
• 532-27-4 1-chloroacetophenone 

Relevant articles and documents

Metabolism of fentanyl and acetylfentanyl in human-induced pluripotent stem cell-derived hepatocytes

To evaluate the capability of human-induced pluripotent stem cell-derived hepatocytes (h-iPS-HEP) in drug metabolism, the profiles of the metabolites of fentanyl, a powerful synthetic opioid, and acetylfentanyl, an N-acetyl analog of fentanyl, in the cells were determined and analyzed. Commercially available h-iPSHEP were incubated with fentanyl or acetylfentanyl for 24 or 48 h. After enzymatic hydrolysis, the medium was deproteinized with acetonitrile, then analyzed by LC/MS. Desphenethylated metabolites and some hydroxylated metabolites, including 4′-hydroxy-fentanyl and β-hydroxy-fentanyl, were detected as metabolites of fentanyl and acetylfentanyl in the medium. The main metabolite of fentanyl with h-iPS-HEP was the desphenethylated metabolite, which was in agreement with in vivo results. These results suggest that h-iPSHEP may be useful as a tool for investigating drug metabolism.