145307-34-2 Usage
Uses
Used in Pharmaceutical Industry:
A-77636 is used as a therapeutic agent for the treatment of Parkinson's disease. It has been shown to increase locomotor activity and reduce disease severity in a marmoset model of Parkinson's disease induced by MPTP. Additionally, it has the potential to be used in the treatment of other psychiatric and neurological disorders due to its selective agonist activity at dopamine D1-like receptors.
Used in Research Applications:
A-77636 is used as a research tool for studying the role of dopamine D1-like receptors in cognition, memory, learning, and motor control. Its selective agonist activity allows researchers to investigate the specific functions and signaling pathways associated with these receptors, contributing to a better understanding of their role in various psychiatric and neurological disorders.
Used in Drug Development:
A-77636 serves as a lead compound in the development of new drugs targeting dopamine D1-like receptors. Its unique properties, such as its selective agonist activity and antiparkinsonian effects, make it a valuable starting point for the design and synthesis of novel therapeutic agents for the treatment of Parkinson's disease and other related disorders.
Biological Activity
Potent and selective dopamine D 1 -like receptor agonist (pEC 50 values are 8.97 and < 5 for D 1 -like and D 2 -like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo .
references
[1]. kebabian jw, britton dr, deninno mp, et al. a-77636: a potent and selective dopamine d1 receptor agonist with antiparkinsonian activity in marmosets. eur j pharmacol, 1992, 229(2-3): 203-209.[2]. lin cw, bianchi br, miller tr, et al. persistent activation of the dopamine d1 receptor contributes to prolonged receptor desensitization: studies with a-77636. j pharmacol exp ther, 1996, 276(3): 1022-1029.[3]. acquas e, day jc, fibiger hc. the potent and selective dopamine d1 receptor agonist a-77636 increases cortical and hippocampal acetylcholine release in the rat. eur j pharmacol, 1994, 260(1): 85-87.
Check Digit Verification of cas no
The CAS Registry Mumber 145307-34-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,3,0 and 7 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 145307-34:
(8*1)+(7*4)+(6*5)+(5*3)+(4*0)+(3*7)+(2*3)+(1*4)=112
112 % 10 = 2
So 145307-34-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H27NO3.ClH/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H/t11?,12?,13?,17-,18-,20?;/m0./s1
