1453081-89-4

Basic information

• Product Name: (4R,5S)-3-((S)-3-((4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-3-(methoxymethoxy)-2,2-dimethylpropanoyl)-5-methyl-4-phenyloxazolidin-2-one
• Synonyms: (4R,5S)-3-((S)-3-((4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-3-(methoxymethoxy)-2,2-dimethylpropanoyl)-5-methyl-4-phenyloxazolidin-2-one
• CAS NO: 1453081-89-4
• Molecular Weight: 447.529
• Mol File: 1453081-89-4.mol

Chemical Properties

• CAS DataBase Reference: (4R,5S)-3-((S)-3-((4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-3-(methoxymethoxy)-2,2-dimethylpropanoyl)-5-methyl-4-phenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-3-((S)-3-((4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-3-(methoxymethoxy)-2,2-dimethylpropanoyl)-5-methyl-4-phenyloxazolidin-2-one(1453081-89-4)
• EPA Substance Registry System: (4R,5S)-3-((S)-3-((4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-3-(methoxymethoxy)-2,2-dimethylpropanoyl)-5-methyl-4-phenyloxazolidin-2-one(1453081-89-4)

Safety Data

• Hazardous Substances Data: 1453081-89-4(Hazardous Substances Data)

Upstream product

• 638211-38-8 (4R,5S)-5-methyl-4-phenyloxazolidin-2-one 
• 1453081-86-1 (4R,5S)-3-(2-bromo-2-methylpropanoyl)-5-methyl-4-phenyloxazolidin-2-one 
• 1453081-88-3 (4R,5S)-3-((S)-3-((4R,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-3-hydroxy-2,2-dimethylpropanoyl)-5-methyl-4-phenyloxazolidin-2-one 
• 107-30-2 chloromethyl methyl ether 
• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 
• 116780-31-5 (1R)-1-((4R,5S)-2,2-dimethyl-5-vinyl[1,3]dioxolan-4-yl)ethane-1,2-diol 
• 116669-78-4 (4S,5S)-2,2-dimethyl-5-vinyl-[1,3]dioxolane-4-carbaldehyde 

Downstream Products

• 1453081-92-9 C₂₃H₃₁NO₈ 
• 1453082-01-3 C₂₄H₃₃NO₈ 

Relevant articles and documents

Towards the total synthesis of Pl-3: Preparation of the eastern fragment through a diastereoselective SmI2-mediated reformatsky reaction

The jatrophane diterpene Pl-3, isolated in 2003 from Euphorbia platyphyllos, is a structurally complex natural product with highly promising biological properties that include pronounced antiproliferative activity and the inhibition of the efflux-pump activity of multidrug resistance p-glycoprotein. Herein, the synthesis of the eastern fragment of Pl-3 is outlined. The target compound is synthesized in nine synthetic operations in good overall yield, starting from readily available D-ribose. The key step in the preparation of the eastern part of Pl-3 is a diastereoselective SmI2-mediated Reformatsky reaction. The proposed route is highly flexible and could also be applied to the synthesis of structurally related jatrophane diterpenes.