1453083-88-9Relevant academic research and scientific papers
NOVEL SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE
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Paragraph 0366; 0368, (2016/11/28)
Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.
NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE
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Paragraph 0329; 0330; 0331, (2014/10/18)
Pharmaceiiticai compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
Homologation as a lead modification approach en route to a series of lactone-based muscarinic ligands
Gao, Rong,Bhandare, Richie R.,Canney, Daniel J.
, p. 1023 - 1030 (2014/03/21)
Previous work identified the lactone ring as a useful scaffold for the design of muscarinic ligands and reported a lactone-based ligand with an IC 50 of 340 nM. Using homologation as a lead modification approach, a new series of lactone-based c
