1453099-73-4Relevant academic research and scientific papers
Reductive iodonio-Claisen rearrangement of iodothiophene diacetates with allylsilanes: Formal synthesis of Plavix
Nguyen, Hai,Khatri, Hem Raj,Zhu, Jianglong
, p. 5464 - 5466 (2013)
Iodothiophene diacetates react with allyltrimethylsilanes in the presence of boron trifluoride diethyl etherate to afford corresponding ortho-allyliodothiophenes via reductive iodonio-Claisen rearrangement. This method has been successfully applied to the synthesis of Plavix, a blood clot inhibitor used to reduce the risk of heart attack and stroke.
