1453110-70-7Relevant academic research and scientific papers
Transition metal-free Minisci reaction promoted by NCS, and TBHP: Acylation of heteroarenes
Siddaraju, Yogesh,Prabhu, Kandikere Ramaiah
, p. 959 - 967 (2016)
A method for acylation for heteroarenes under metal-free conditions has been described using NCS as an additive and TBHP as an oxidant. This method has been successfully employed in acylation of a variety of aldehyde with heteroarenes. The application of the method has been illustrated in synthesizing isoquinoline derived natural products. This strategy provides an efficient, mild and inexpensive method for acylation of heteroarenes.
TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes
Chen, Jiayu,Wan, Miao,Hua, Jing,Sun, Yi,Lv, Zheng,Li, Wei,Liu, Lei
, p. 11561 - 11566 (2015/12/04)
An effective and metal-free oxidative cross-dehydrogenative coupling (CDC) of N-heterocycles with diverse aldehydes has been established in the presence of TBHP/TFA. The scope with respect to aldehyde and N-heterocycle components is broad, allowing facile synthesis of a broad range of structurally diverse C1-acyl substituted heterocycles in good efficiency.
A transition metal-free Minisci reaction: Acylation of isoquinolines, quinolines, and quinoxaline
Siddaraju, Yogesh,Lamani, Manjunath,Prabhu, Kandikere Ramaiah
, p. 3856 - 3865 (2014/05/20)
Transition metal-free acylation of isoquinoline, quinoline, and quinoxaline derivatives has been developed employing a cross dehydrogenative coupling (CDC) reaction with aldehydes using substoichiometric amount of TBAB (tetrabutylammonium bromide, 30 mol %) and K2S2O 8 as an oxidant. This intermolecular acylation of electron-deficient heteroarenes provides an easy access and a novel acylation method of heterocyclic compounds. The application of this CDC strategy for acylation strategy has been illustrated in synthesizing isoquinoline-derived natural products.
