1453171-96-4

Basic information

• Product Name: 4-(tert-butyldimethylsilyloxy)-4-phenyl-1-(pyrrolidin-1-yl)butan-1-one
• Synonyms: 4-(tert-butyldimethylsilyloxy)-4-phenyl-1-(pyrrolidin-1-yl)butan-1-one
• CAS NO: 1453171-96-4
• Molecular Weight: 347.573
• Mol File: 1453171-96-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(tert-butyldimethylsilyloxy)-4-phenyl-1-(pyrrolidin-1-yl)butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(tert-butyldimethylsilyloxy)-4-phenyl-1-(pyrrolidin-1-yl)butan-1-one(1453171-96-4)
• EPA Substance Registry System: 4-(tert-butyldimethylsilyloxy)-4-phenyl-1-(pyrrolidin-1-yl)butan-1-one(1453171-96-4)

Safety Data

• Hazardous Substances Data: 1453171-96-4(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 99802-88-7 4-hydroxy-4-phenyl-1-(pyrrolidine-1-yl)butan-1-one 

Downstream Products

• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 

Relevant articles and documents

Direct room-temperature lactonisation of alcohols and ethers onto amides: An "amide strategy" for synthesis

Last-minute deal: A direct lactonisation of ethers and alcohols onto amides that proceeds at room temperature under mild conditions is reported (see scheme). This allows the effective saving of up to two unproductive, sequential deprotection operations in synthetic sequences. Mechanistic studies are described, and a new "amide strategy" that exploits the dual robustness/late-stage selective activation properties of this functional group is outlined. Copyright