1453172-01-4Relevant academic research and scientific papers
Direct room-temperature lactonisation of alcohols and ethers onto amides: An "amide strategy" for synthesis
Valerio, Viviana,Petkova, Desislava,Madelaine, Claire,Maulide, Nuno
, p. 2606 - 2610 (2013/03/14)
Last-minute deal: A direct lactonisation of ethers and alcohols onto amides that proceeds at room temperature under mild conditions is reported (see scheme). This allows the effective saving of up to two unproductive, sequential deprotection operations in synthetic sequences. Mechanistic studies are described, and a new "amide strategy" that exploits the dual robustness/late-stage selective activation properties of this functional group is outlined. Copyright
