1453186-39-4Relevant articles and documents
Ruthenium-catalyzed selective aerobic oxidative ortho-alkenylation of substituted phenols with alkenes through C-H bond activation
Reddy, Mallu Chenna,Jeganmohan, Masilamani
supporting information, p. 1150 - 1157 (2013/04/10)
The oxidative coupling of phenyl carbamates and acetates with alkenes in the presence of a catalytic amount of [RuCl2(p-cymene)]2, AgSbF6, and Cu(OAc)2·H2O under air provided substituted alkene derivatives in a highly regio- and stereoselective manner. The catalytic reaction was compatible with various alkenes such as acrylates, vinyl sulfones, acrylonitrile, and substituted styrenes. The present catalytic reaction was also compatible with phenyl carbamates and acetates with various electron-rich, electron-deficient, and halogen substituents on the aromatic ring. Further examination of the catalytic reaction was done with the substituted phenyl acetates. By using LiOH·H2O or K 2CO3 as a base, the substituted alkene derivatives were converted into the corresponding phenol derivatives. To account for the catalytic reaction, a possible mechanism is proposed that involves a six-membered ruthenacycle as the key intermediate. The oxidative coupling of substituted phenyl carbamates and acetates with alkenes in the presence of [RuCl2(p-cymene)]2, AgSbF6, and Cu(OAc) 2·H2O provided substituted alkene derivatives in a highly regio- and stereoselective manner. In the presence of either LiOH·H2O or K2CO3, ortho-alkenylated phenyl carbamates and acetates were converted into the corresponding phenols. Copyright
