1453205-11-2

Basic information

• Product Name: C₂₀H₂₂N₂O₂
• CAS NO: 1453205-11-2
• Molecular Weight: 322.407
• Mol File: 1453205-11-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₂N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₂N₂O₂(1453205-11-2)
• EPA Substance Registry System: C₂₀H₂₂N₂O₂(1453205-11-2)

Safety Data

• Hazardous Substances Data: 1453205-11-2(Hazardous Substances Data)

Upstream product

• 78703-01-2 C₁₆H₁₆ClNO₂ 
• 79668-76-1 3-(3-chloropropoxy)benzenamine 
• 591-27-5 m-Hydroxyaniline 

Relevant articles and documents

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity

Lysine demethylases play an important role in epigenetic regulation and thus in the development of diseases like cancer or neurodegenerative disorders. As the lysine specific demethylase 1 (LSD1/KDM1) has been strongly connected to androgen and estrogen dependent gene expression, it serves as a promising target for the therapy of hormone dependent cancer. Here, we report on the discovery of new small molecule inhibitors of LSD1 containing a propargylamine warhead, starting out from lysine containing substrate analogues. On the basis of these substrate mimicking inhibitors, we were able to increase potency by a combination of similarity-based virtual screening and subsequent synthetic optimization resulting in more druglike LSD1 inhibitors that led to histone hypermethylation in breast cancer cells.