1453211-47-6 Usage
Core Structure
Pyrimidine core
Functional Groups
Iodine Atom: Attached at the 5-position
Methoxy Group: Attached at the 3-position
Substituted Phenyl Ring:
Piperidin-1-yl Group: Attached
Methylpiperazin-1-yl Group: Attached
Functionalization
Highly functionalized molecule
Potential Pharmacological Applications
Structural Features: Amino and heterocyclic groups present
Candidate for Interaction: Potential interaction with biological targets
Potentiation of Therapeutic Effects: Potential utility in pharmacological interventions
Need for Further Characterization and Evaluation
To Understand Biological Activity: Detailed analysis required
Exploration of Potential Applications: Assessment of pharmacological and therapeutic utility
Check Digit Verification of cas no
The CAS Registry Mumber 1453211-47-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,3,2,1 and 1 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1453211-47:
(9*1)+(8*4)+(7*5)+(6*3)+(5*2)+(4*1)+(3*1)+(2*4)+(1*7)=126
126 % 10 = 6
So 1453211-47-6 is a valid CAS Registry Number.
1453211-47-6Relevant articles and documents
Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency
Kuriwaki, Ikumi,Kameda, Minoru,Iikubo, Kazuhiko,Hisamichi, Hiroyuki,Kawamoto, Yuichiro,Kikuchi, Shigetoshi,Moritomo, Hiroyuki,Kondoh, Yutaka,Terasaka, Tadashi,Amano, Yasushi,Tateishi, Yukihiro,Echizen, Yuka,Iwai, Yoshinori,Noda, Atsushi,Tomiyama, Hiroshi,Nakazawa, Taisuke,Hirano, Masaaki
, (2021)
Fibroblast growth factor receptor 3 (FGFR3) is an attractive therapeutic target for the treatment of patients with bladder cancer harboring genetic alterations in FGFR3. We identified pyrimidine derivative 20b, which induced tumor regression following ora