1453211-72-7

Usage

Chemical structure

A pyrazole derivative with a chloro and nitro group attached to a phenoxyethyl group

Usage

Commonly used as a building block in organic synthesis and pharmaceutical research

Potential applications

Agricultural chemical, insecticidal and fungicidal properties

Research areas

Medicinal chemistry, anti-cancer agent, treatment for neurodegenerative diseases

Ongoing research

Exploring various potential uses in different fields

Upstream product

• 288-13-1 NH-pyrazole 
• 3062-53-1 2-(2-bromoethoxy)-1-chloro-4-nitrobenzene 

Downstream Products

• 1453211-73-8 (3R,5S)-3,5-dimethyl-1-{4-nitro-2-[2-(1H-pyrazol-1-yl)ethoxy]phenyl}piperazine 

Relevant academic research and scientific papers

NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.