1453315-80-4

Usage

Molecular structure

A complex spirocyclic structure composed of a tert-butyl group, an ethyl group, and two carboxylate groups attached to a 7-oxo-5-oxa-2-azaspiro[3.4]octane ring system.

Biological activity

Potential applications in medicinal chemistry due to the diverse biological activities of spirocyclic compounds.

Pharmacokinetic properties

tert-butyl and ethyl substituents may enhance the compound's pharmacokinetic properties.

Further research needed

More research and investigation is required to fully understand the potential of 2-(tert-butyl) 8-ethyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2,8-dicarboxylate.

Upstream product

• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 96-35-5 glycolic acid methyl ester 
• 1002355-96-5 tert-butyl 3-(2-ethoxy-2-oxoethylidene)azetidine-1-carboxylate 

Downstream Products

• 1408075-90-0 tert-butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate 
• 1408074-46-3 tert-butyl 7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2- carboxylate 

Relevant academic research and scientific papers

CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS

The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.

DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS

Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS

The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula (I), where R1, R2, R3, R4, R5, R5', R6, R7, X, m, and n are described herein.

Construction of multifunctional modules for drug discovery: Synthesis of novel thia/oxa-azaspiro[3.4]octanes

New classes of thia/oxa-azaspiro[3.4]octanes are synthesized through the implementation of robust and step-economic routes. The targeted spirocycles have been designed to act as novel, multifunctional, and structurally diverse modules for drug discovery.