145337-58-2

Upstream product

• 622-33-3 N-benzyloxyamine 
• 20312-37-2 (R)-2-hydroxy-4-methylpentanoic acid 
• 37755-48-9 benzyl (R)-2-hydroxy-4-methylpentanoate 
• 184948-24-1 tert-butyl (2R)-1,2-dibenzyl 4-methylpentane-1,1,2-tricarboxylate 
• 209978-01-8 (2R)-4-methyl-2-((1-methyl-1-t-butoxy-carbonyl)methyl)pentanoic acid 
• 130317-28-1 benzyl 2R-trifluoromethanesulfonyloxy-4-methylvalerate 

Relevant academic research and scientific papers

Design and synthesis of the cartilage protective agent (CPA, Ro32-3555)

A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage protective agent for use in the treatment of rheumatoid- and osteoarthritis.