1453393-82-2

Upstream product

• 473537-32-5 5-methoxy-2-nitro-4-(trifluoromethyl)aniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 35375-74-7 5-chloro-2-nitro-4-(trifluoromethyl)aniline 
• 400-70-4 2,4-dichloro-5-nitrobenzotrifluoride 

Downstream Products

• 473537-73-4 2-amino-1-(tert-butoxycarbonylamino)-5-methoxy-4-(trifluoromethyl)benzene 
• 1453393-60-6 4-[3’-(1''H-imidazol-1''-yl)phenyl]-7-methoxy-8-trifluoromethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one 
• 1453393-95-7 1-(tert-butoxycarbonylamino)-2-{3'-[3''-(1'''H-imidazol-1'''-yl)phenyl]-3'-oxopropanamido}-5-methoxy-4-(trifluoromethyl)benzene 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5- benzodiazepin-2-ones; Potential imaging agents of the metabotropic glutamate 2 receptor

A focused library of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones containing sites for 11C-, 18F- and 123I- labelling have been prepared and evaluated against membrane expressing human recombinant metabotropic glutamate 2 receptor (mGluR2). The compounds were found to be non-competitive antagonists with nanomolar affinity. HPLC evaluation of the physiochemical properties of these compounds identified two candidates for PET and SPECT imaging of mGluR2.