1453462-25-3Relevant academic research and scientific papers
Synthetic studies on hemicalide: Development of a convergent approach toward the C1-C25 fragment
Sorin, Geoffroy,Fleury, Etienne,Tran, Christine,Prost, Elise,Molinier, Nicolas,Sautel, Francois,Massiot, Georges,Specklin, Simon,Meyer, Christophe,Cossy, Janine,Lannou, Marie-Isabelle,Ardisson, Janick
, p. 4734 - 4737 (2013)
Synthetic studies on hemicalide, a recently isolated marine natural product displaying highly potent antiproliferative activity and a unique mode of action, have highlighted a reliable Horner-Wadsworth-Emmons olefination to create the C6-C7 alkene and a remarkable efficient Suzuki-Miyaura coupling to form the C15-C16 bond, resulting in the development of a convergent approach toward the C1-C25 fragment.
