1453489-06-9Relevant academic research and scientific papers
Design, synthesis, biological activity and structure-activity relationship studies of chalcone derivatives as potential anti-Candida agents
Andrade, Jéssica T.,Santos, Felipe R. S.,Lima, William G.,Sousa, Carla D. F.,Oliveira, Lohanna S. F. M.,Ribeiro, Rosy I. M. A.,Gomes, Ana J. P. S.,Araújo, Marcelo G. F.,Villar, José A. F. P.,Ferreira, Jaqueline M. S.
, p. 702 - 712 (2018)
Vulvovaginal candidiasis (VVC) affects millions of women around the world every year. Candida albicans is the most frequently isolated pathogen in women and its rapid ability to develop resistance to first and second line therapies has boosted the search
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles
Fioravanti, Rossella,Desideri, Nicoletta,Biava, Mariangela,Proietti Monaco, Luca,Grammatica, Laura,Yá?ez, Matilde
, p. 5128 - 5130 (2013/09/12)
A series of 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles (3a-k and 4a-u) were designed, synthesized, and evaluated for their inhibitory efficacy towards the two hMAO isoforms. Most of the derivatives were found to be potent and selective hMAO-B inhibitors. In particular, derivative 3g showed greater hMAO-B affinity than selective inhibitor selegiline coupled with high selectivity index (SI = 145). The most selective hMAO-B inhibitor was the 3-methyl analogue 3f with an SI higher than 909.
