1453494-27-3

Basic information

• Product Name: C₁₃H₁₂F₃NO
• Synonyms: C₁₃H₁₂F₃NO
• CAS NO: 1453494-27-3
• Molecular Weight: 255.24
• Mol File: 1453494-27-3.mol

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₂F₃NO(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₂F₃NO(1453494-27-3)
• EPA Substance Registry System: C₁₃H₁₂F₃NO(1453494-27-3)

Safety Data

• Hazardous Substances Data: 1453494-27-3(Hazardous Substances Data)

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 122924-26-9 3--2-cyclohexen-1-one 

Downstream Products

• 400747-98-0 4'-(trifluoromethyl)-[1,1'-biphenyl]-3-amine 

Relevant articles and documents

Synthesis of chiral seven-membered β-substituted lactams: Via Rh-catalyzed asymmetric hydrogenation

Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation of seven-membered β-substituted α,β-unsaturated lactams was successfully developed to prepare various chiral seven-membered β-substituted lactams with good to excellent results (up to >99% conversion, 99% yield, and >99% ee).

Pd-catalyzed Semmler-Wolff reactions for the conversion of substituted cyclohexenone oximes to primary anilines

Homogeneous Pd catalysts have been identified for the conversion of cyclohexenone and tetralone O-pivaloyl oximes to the corresponding primary anilines and 1-aminonaphthalenes. This method is inspired by the Semmler-Wolff reaction, a classic method that exhibits limited synthetic utility owing to its forcing conditions, narrow scope, and low product yields. The oxime N-O bond undergoes oxidative addition to Pd0(PCy3)2, and the product of this step has been characterized by X-ray crystallography and shown to undergo dehydrogenation to afford the aniline product.