145353-99-7Relevant academic research and scientific papers
γ-Pyrone compounds. II: Synthesis and antiplatelet effects of tetraoxygenated xanthones
Lin,Liou,Ko,Teng
, p. 1109 - 1112 (1992)
Norathyriol and its analogues, 1,3,5,6-, 3,4,5,6-, 3,4,6,7- and 2,3,6,7- tetrahydroxyxanthone, were synthesized from benzophenone precursors by Friedel-Crafts acylation and subsequent base-catalyzed cyclization to eliminate methanol. Both 3,4,6,7- and 2,3,6,7-tetrahydroxyxanthone tetraacetate showed potent anti-platelet aggregation effects on arachidonic acid-induced platelet aggregation. 3,4,6,7-Tetrahydroxyxanthone tetraacetate and 1,3,5,6-tetrahydroxyxanthone showed potent and significant anti-platelet aggregation effects on collagen-induced platelet aggregation.
Relationship between protective effect of xanthone on endothelial cells and endogenous nitric oxide synthase inhibitors
Jiang, De-Jian,Hu, Gao-Yun,Jiang, Jun-Lin,Xiang, Hong-Lin,Deng, Han-Wu,Li, Yuan-Jian
, p. 5171 - 5177 (2003)
1,3,5,6-tetrahydroxyxanthone was synthesized. The relationship between protective effect of xanthone on endothelial cells and endogenous nitric oxide synthase inhibitors was investigated. Endothelial cells were treated with ox-LDL (100 μg/mL) for 48 h. Ad
