1453810-07-5

Basic information

• Product Name: 3-hydroxy-1-(naphthalen-2-yl)-5-phenyl-3-(trifluoromethyl)pent-4-yn-1-one
• Synonyms: 3-hydroxy-1-(naphthalen-2-yl)-5-phenyl-3-(trifluoromethyl)pent-4-yn-1-one
• CAS NO: 1453810-07-5
• Molecular Weight: 368.355
• Mol File: 1453810-07-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-1-(naphthalen-2-yl)-5-phenyl-3-(trifluoromethyl)pent-4-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-1-(naphthalen-2-yl)-5-phenyl-3-(trifluoromethyl)pent-4-yn-1-one(1453810-07-5)
• EPA Substance Registry System: 3-hydroxy-1-(naphthalen-2-yl)-5-phenyl-3-(trifluoromethyl)pent-4-yn-1-one(1453810-07-5)

Safety Data

• Hazardous Substances Data: 1453810-07-5(Hazardous Substances Data)

Upstream product

• 893-33-4 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedione 
• 536-74-3 phenylacetylene 

Downstream Products

• 1453810-23-5 2-(naphthalen-2-yl)-6-phenyl-4-(trifluoromethyl)pyridine 

Relevant articles and documents

Synthesis of 4-trifluoromethylpyridines by [5+1] cyclization of 3-hydroxy-pent-4-yn-1-ones with urea

Trifluoromethyl-substituted 1,3-diketones can undergo direct alkynylation reactions which are not possible for alkyl- or aryl-substituted derivatives. The products can be easily transformed into 2,6-diaryl-4-trifluoromethylpyridines by acid-mediated [5+1] cyclization with urea. The reaction was thoroughly optimized by variation of the conditions and the scope was studied in detail. The products are not readily available by other methods. A plausible mechanism was suggested based on DFT calculations.