1453834-21-3
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Basic information
- Product Name: LDC4297
- Synonyms: LDC4297;LDC4297(LDC044297)
- CAS NO:1453834-21-3
- Molecular Formula: C23H28N8O
- Molecular Weight: 432.52142
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1453834-21-3.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: LDC4297(CAS DataBase Reference)
- NIST Chemistry Reference: LDC4297(1453834-21-3)
- EPA Substance Registry System: LDC4297(1453834-21-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1453834-21-3(Hazardous Substances Data)
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1453834-21-3 Usage
Description
LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7; IC50 = <5 nM). It is selective for CDK7 over CDK4, CDK6, and CDK9 (IC50s = >10, >10, and 1.71 μM), however, it also inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human cytomegalovirus (HCMV) replication in human fibroblasts (EC50 = 24.5 nM). LDC-4297 also reduces replication of Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae family viruses (EC50s = 0.02-1.13 μM).Uses
Cyclin-dependent protein kinase 7 (CDK7) is involved with a broad range of regulatory roles in cell cycle and transcription, which is essential for viral replication. LDC 4297 is a CDK7 inhibitor that can be used to develop antiviral drugs.Check Digit Verification of cas no
The CAS Registry Mumber 1453834-21-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,3,8,3 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.Calculate Digit Verification of CAS Registry Number 1453834-21:
(9*1)+(8*4)+(7*5)+(6*3)+(5*8)+(4*3)+(3*4)+(2*2)+(1*1)=163
163 % 10 = 3
So 1453834-21-3 is a valid CAS Registry Number.
1453834-21-3Upstream product
1453834-21-3Downstream Products
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LDC4297
