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(S)-1-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1453847-89-6

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1453847-89-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1453847-89-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,3,8,4 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1453847-89:
(9*1)+(8*4)+(7*5)+(6*3)+(5*8)+(4*4)+(3*7)+(2*8)+(1*9)=196
196 % 10 = 6
So 1453847-89-6 is a valid CAS Registry Number.

1453847-89-6Downstream Products

1453847-89-6Relevant articles and documents

Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2

Ren, Li,Grina, Jonas,Moreno, David,Blake, James F.,Gaudino, John J.,Garrey, Rustam,Metcalf, Andrew T.,Burkard, Michael,Martinson, Matthew,Rasor, Kevin,Chen, Huifen,Dean, Brian,Gould, Stephen E.,Pacheco, Patricia,Shahidi-Latham, Sheerin,Yin, Jianping,West, Kristina,Wang, Weiru,Moffat, John G.,Schwarz, Jacob B.

, p. 1976 - 1991 (2015/04/27)

Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of (S)-14k, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On the basis of its in vivo efficacy and preliminary safety profiles, (S)-14k was selected for further preclinical evaluation.

SERINE/THREONINE KINASE INHIBITORS

-

, (2013/09/12)

Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

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