1453849-68-7Relevant academic research and scientific papers
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development
Blake, James F.,Burkard, Michael,Chan, Jocelyn,Chen, Huifen,Chou, Kang-Jye,Diaz, Dolores,Dudley, Danette A.,Gaudino, John J.,Gould, Stephen E.,Grina, Jonas,Hunsaker, Thomas,Liu, Lichuan,Martinson, Matthew,Moreno, David,Mueller, Lars,Orr, Christine,Pacheco, Patricia,Qin, Ann,Rasor, Kevin,Ren, Li,Robarge, Kirk,Shahidi-Latham, Sheerin,Stults, Jeffrey,Sullivan, Francis,Wang, Weiru,Yin, Jianping,Zhou, Aihe,Belvin, Marcia,Merchant, Mark,Moffat, John,Schwarz, Jacob B.
, p. 5650 - 5660 (2016/07/06)
The extracellular signal-regulated kinases ERK1/2 represent an essential node within the RAS/RAF/MEK/ERK signaling cascade that is commonly activated by oncogenic mutations in BRAF or RAS or by upstream oncogenic signaling. While targeting upstream nodes
