1453874-77-5Relevant academic research and scientific papers
Gold(I)-Catalyzed Oriented Assembly of Dihydropyridines
Li, Yufeng,Wu, Zhengguang,Pan, Yi,Huang, Hao,Shi, Jie,Bu, Hongzhong,Ma, Hongfei,Liang, Yingying,Huang, Binbin
, p. 834 - 838 (2015)
A novel method for the assembly of multisubstitued dihydropyridines has been developed starting from methyl propiolate and propargylamines. The reactions were efficiently catalyzed by AuPPh3Cl to get high regioselectivity and high yields. And alternatively, since propargylamines could be easily derived by the CuCl-mediated addition of methyl propiolate to imines, the reactions could be carried out as a sequential three-component model.
An atom-economic synthesis of functionalized pyrroles via a sequential metal-catalyzed three-component reaction
Li, Yufeng,Jie, Shi,Wu, Zhengguang,Wang, Xinglong,Wu, Xiaowei,Gu, Jiachao,Bu, Hongzhong,Ma, Hongfei
supporting information, p. 2472 - 2477 (2014/04/03)
A three-component reaction of one molecule of imine and two molecules of alkynoates is realized with the catalysis of Cu(I)-Fe(III) in a sequential manner to allow the direct synthesis of functionalized pyrroles, during which, one C-N bond and two C-C bonds are formed with high atom economy. This method benefits from easily available starting materials, low-cost catalysts, and convenient operations.
