1454270-52-0Relevant articles and documents
An improved synthesis of [11C]MENET via Suzuki coupling with [11C]methyl iodide
Zeng, Fanxing,Voll, Ronald J.,Crowe, Ronald J.,Waldrep, Michael S.,Dolph, Karen B.,Goodman, Mark M.
, p. 307 - 309 (2013)
[11C]MENET, a promising norepinephrine transporter imaging agent, was prepared by Suzuki cross coupling of 1 mg N-t-Boc pinacolborate precursor with [11C]CH3I in DMF using palladium complex generated in situ from Pd2(dba)3 and (o-CH 3C6H4)3P together with K 2CO3 as the co-catalyst, followed by deprotection with trifluoroacetic acid. This improved radiolabeling method provided [ 11C]MENET in high radiochemical yield at end of synthesis (EOS, 51 ± 3%, decay-corrected from end of 11CH3I synthesis, n = 6), moderate specific activity (1.5-1.9 Ci/μmol at EOS), and high radiochemical (>98%) and chemical purity (>98%) in a synthesis time of 60 ± 5 min from the end of bombardment. Copyright