145428-03-1

Basic information

• Product Name: (N-Benzyloxycarbonyl-L-valyl-L-phenylalanyl)diazomethane
• CAS NO: 145428-03-1
• Molecular Weight: 422.484
• Mol File: 145428-03-1.mol

Chemical Properties

• CAS DataBase Reference: (N-Benzyloxycarbonyl-L-valyl-L-phenylalanyl)diazomethane(CAS DataBase Reference)
• NIST Chemistry Reference: (N-Benzyloxycarbonyl-L-valyl-L-phenylalanyl)diazomethane(145428-03-1)
• EPA Substance Registry System: (N-Benzyloxycarbonyl-L-valyl-L-phenylalanyl)diazomethane(145428-03-1)

Safety Data

• Hazardous Substances Data: 145428-03-1(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 19542-51-9 N-benzyloxycarbonyl-L-valyl-L-phenylalanine 

Relevant articles and documents

Enantiopure N-protected α-amino glyoxals 1. Synthesis from α-amino acids and some condensation reactions with amines

A series of N-protected α-ammo diazoketones has been prepared from L-amino acids and dipeptides and used as precursors in the synthesis of novel N-protected α-amino glyoxals via oxidation with distilled dimethyldioxirane (DMD) in acetone. The glyoxals have been converted, without purification, into enantiopure imines, pyrazines, quinoxalines, and pyrido[2,3-b]pyrazines via condensation with the appropriate amine or diamine. The molecular structure of the pyrido[2,3-b]pyrazine derived from N-Cbz-L-phenylalanine has been determined by X-ray analysis.

Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl α-keto aldehyde (glyoxals)

A series of peptidyl α-keto aldehydes (glyoxals) have been synthesised as putative inhibitors of the chymotryptic-like activity of proteasome. The most potent peptides, Cbz-Leu-Leu-Tyr-COCHO and Bz-Leu-Leu-Leu-COCHO, function as slow-binding reversible inhibitors, exhibiting final K(i) values of approximately 3.0 nM. These are among the lowest values so far reported for (tri)peptide-based aldehyde-releated inhibitors.