145439-13-0

Basic information

• Product Name: Benzoic acid, 2-(2,5-dihydro-5-oxo-3-furanyl)-, methyl ester
• CAS NO: 145439-13-0
• Molecular Formula: C12H10O4
• Molecular Weight: 218.209
• Mol File: 145439-13-0.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(2,5-dihydro-5-oxo-3-furanyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(2,5-dihydro-5-oxo-3-furanyl)-, methyl ester(145439-13-0)
• EPA Substance Registry System: Benzoic acid, 2-(2,5-dihydro-5-oxo-3-furanyl)-, methyl ester(145439-13-0)

Safety Data

• Hazardous Substances Data: 145439-13-0(Hazardous Substances Data)

Upstream product

• 610-97-9 o-iodo-methyl-benzoic acid 
• 145439-09-4 4-(tributylstannyl)-2,5-dihydrofuran-2-one 
• 57061-30-0 4-Phenylsulfanylfuran-2(5H)-one 

Relevant articles and documents

Preparation and reactions of 3,4-bisstannyl-2(5H)furanones

Bistributylstannyl-2(5H)-furanone 4a has been prepared from 3-(tetrahydropyran-2-yl)oxy but-2-ynoate and shown to exhibit good selectivity in its Stille reactions with a range of halogenated compounds, leading to 4-substituted-3-stannyl-2(5H)-furanones, in generally moderate yield. Under certain reaction conditions, doubly substituted products were also isolated from the reactions. The 3,4-bistrimethylstannyl furanone, 4b, corresponding to 4a was prepared, but decomposed during all attempts to execute Stille reactions upon it.

Preparation and palladium-catalysed cross-coupling reactions of 3-and 4-tributylstannylfuran-2(5H)-ones

Stannylfuranones 1 and 2 were prepared by ipso radical desulfurative stannylation of phenylsulfanylfuranones 3 and 16. Compounds 1 and 2 underwent Stille coupling reactions with aryl iodides to give 3- and 4-arylfuran-2(5H)-ones.

Preparation and reactions of 3-and 4-tributylstannyl-2-(5H)-furanones: Preparation of aryl furanones

3- and 4-trialkylstannylfuranones (2) and (3) have been prepared by an interesting desulphurative stannylation reaction; 3- and 4-substituted 2-(5H)-Furanones (12) and (13) may be prepared via palladium-catalysed cross coupling of (2) and (3) with aryl iodides.