145441-04-9

Basic information

• Product Name: (2E)-N-(2,6-dimethylphenyl)-3-(5-methylisoxazol-3-yl)prop-2-enamide
• CAS NO: 145441-04-9
• Molecular Formula: C₁₅H₁₆N₂O₂
• Molecular Weight: 256.2997
• Mol File: 145441-04-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 471.6°C at 760 mmHg
• Flash Point: 239°C
• Density: 1.185g/cm³
• Vapor Pressure: 4.59E-09mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: (2E)-N-(2,6-dimethylphenyl)-3-(5-methylisoxazol-3-yl)prop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-N-(2,6-dimethylphenyl)-3-(5-methylisoxazol-3-yl)prop-2-enamide(145441-04-9)
• EPA Substance Registry System: (2E)-N-(2,6-dimethylphenyl)-3-(5-methylisoxazol-3-yl)prop-2-enamide(145441-04-9)

Safety Data

• Hazardous Substances Data: 145441-04-9(Hazardous Substances Data)

Upstream product

• 62254-74-4 5-methyl-isoxazole-3-carbaldehyde 
• 87-62-7 2,6-dimethylaniline 

Relevant articles and documents

New N-aryl isoxazolecarboxamides and N-isoxazolylbenzamides as anticonvulsant agents

We prepared a series of N-aryl isoxazolecarboxamide, N-isoxazolylbenzamide compounds and derivatives and studied their anticonvulsant action in MES and MMS tests. Some of these reveal considerable activity, especially with respect to MES test. The disubstitution in the 2.6-position on the phenyl ring by two methyl groups would appear to be of primary importance for the activity. The amide bridge between the phenyl and isoxazolic rings, whether of the anilide or benzamide type, seems to show similar anticonvulsant behavior. We have selected the derivatives 8 (N-(2.6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide, 12 (N-(2.6-dimethylphenyl)-5-hydroxymethyl-3-isoxazolecarboxamide) and 51 (N-(5-methyl-3-isoxazolyl)-2.6-dimethylbenzamide) which are presently being studied in more extended pharmacological tests.