145441-16-3

Usage

Chemical Class

Isoxazolecarboxylic acids

Pharmaceutical and Agrochemical Applications

Known for various applications in pharmaceutical and agrochemical industries.

Functional Group

Contains a fluoromethyl group at the 5th position of the isoxazole ring.

Biological Activity and Pharmacological Properties

The fluoromethyl group may contribute to biological activity and pharmacological properties.

Chemical Reactivity

The presence of the fluoromethyl group can influence chemical reactivity.

Physical Properties

Likely to exhibit altered physical properties due to the presence of the fluoromethyl group.

Potential Uses

May be utilized in drug discovery and development.

Synthesis

Can be used in the synthesis of other chemical compounds with similar structural features.

Research Need

Further research and investigation are necessary to understand its full potential applications and properties.

Upstream product

• 123770-62-7 ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate 
• 215872-15-4 ethyl 5-(fluoromethyl)isoxazole-3-carboxylate 

Downstream Products

• 139297-39-5 N-(2,6-dimethylphenyl)-5-fluoromethyl-3-isoxazolecarboxamide 

Relevant academic research and scientific papers

Positive allosteric modulators of the nicotinic acetylcholine receptor

The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.

Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as GABA alpha 5 ligands

Substituted 1,2,4-Triazolo[3,4-A]phthalazine derivatives are GABA Alpha 5 ligands and are represented by the formula

New N-aryl isoxazolecarboxamides and N-isoxazolylbenzamides as anticonvulsant agents

We prepared a series of N-aryl isoxazolecarboxamide, N-isoxazolylbenzamide compounds and derivatives and studied their anticonvulsant action in MES and MMS tests. Some of these reveal considerable activity, especially with respect to MES test. The disubstitution in the 2.6-position on the phenyl ring by two methyl groups would appear to be of primary importance for the activity. The amide bridge between the phenyl and isoxazolic rings, whether of the anilide or benzamide type, seems to show similar anticonvulsant behavior. We have selected the derivatives 8 (N-(2.6-dimethylphenyl)-5-methyl-3-isoxazolecarboxamide, 12 (N-(2.6-dimethylphenyl)-5-hydroxymethyl-3-isoxazolecarboxamide) and 51 (N-(5-methyl-3-isoxazolyl)-2.6-dimethylbenzamide) which are presently being studied in more extended pharmacological tests.