145449-65-6Relevant academic research and scientific papers
Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of Tau aggregation
Ballatore, Carlo,Brunden, Kurt R.,Piscitelli, Francesco,James, Michael J.,Crowe, Alex,Yao, Yuemang,Hyde, Edward,Trojanowski, John Q.,Lee, Virginia M.-Y.,Smith, Amos B.
, p. 3739 - 3747 (2010)
Agents capable of preventing the misfolding and sequestration of the microtubule-stabilizing protein tau into insoluble fibrillar aggregates hold considerable promise for the prevention and/or treatment of neurodegenerative tauopathies such as Alzheimer's
