145452-23-9Relevant academic research and scientific papers
Asymmetric Synthesis of α-Amino Acids via Cationic Aza-Cope Rearrengements
Agami, Claude,Couty, Francois,Lin, Jing,Mikaeloff, Axelle,Poursoulis, Michel
, p. 7239 - 7250 (1993)
Ene-iminium intermediates resulting from reaction between glyoxal and β-amino alcohols rearrange by an aza-Cope process.Three different tandem reactions are thus carried out; their first component is this cationic rearrangement, the second step being either an iminium hydrolysis, a nucleophile-induced ene-iminium cyclization or a Mannich reaction.The last two sequences lead to homochiral proline derivatives.
