145458-60-2Relevant academic research and scientific papers
Reductive routes to rigid peptide building blocks: The dependence of a regioselective imide reduction on the nature of an α-alkoxy substituent
Moeller,Hanau
, p. 6041 - 6044 (1992)
The reduction of several N-acylpyrrolidinones has been studied. The regioselectivity of the reductions was found to depend on the nature of the N-acyl group. In one example, the use of a sterically bulky triisopropylsiloxy substituent alpha to the N-acyl carbonyl led to exclusive reduction of the pyrrolidinone carbonyl and the formation of a product that could be used in the synthesis of the 1-azabicyclo[5.3.0]decane ring skeleton found in a key bicyclic Pro-Phe building block.
