145459-67-2Relevant academic research and scientific papers
AMINOOXYALKYLPHOSPHONIC ACIDS AND DERIVATIVES
Maier, Ludwig
, p. 119 - 122 (2007/10/02)
The preparation, reactions, and biological activity of 1-aminooxyalkylphosphonic- and phosphinic acids and derivatives are reported.
ORGANIC PHOSPHORUS COMPOUNDS 102. AMINOOXYALKYLPHOSPHONIC ACIDS AND DERIVATIVES
Maier, Ludwig,Spoerri, H.
, p. 39 - 48 (2007/10/02)
Condensation of α-hydroxyalkylphosphonates, 1, with N-hydroxy-phthalimide using Mitsunobu's condition yields 1-phthalimido-N-oxyalkylphosphonates, 2, which on treatment with hydrazine give 1-aminooxyalkylphosphonates, 3.Hydrolysis of these with HCl produces 1-aminooxyalkylphosphonic acids, 4, in good yields.The reactions of 3 with dinitrodiphenyl ether, isocyanides, aldehydes and ketones are also reported. 1-Aminooxy-2-phenylethylphosphonic acid, 4g, is only a weak inhibitor of PAL, but 4i is a good inhibitor of anthocyanin synthesis.4g exhibits weak antifungal activity (against Botrytis cinerea) and 5a and 5b show herbicidal activity against dicotyledonous weeds. Key words: 1-Aminooxyalkylphosphonates; 1-aminooxyalkylphosphonic acids; physical properties; NMR-spectra; biological activity.
