14546-73-7

Usage

Uses

Used in Pharmaceutical Industry:
(+)-(1S)-1,2,3,4-tetrahydro-1-benzyl-6,7-dimethoxyquinoline hydrochloride is used as a therapeutic agent for the treatment of Parkinson's disease and other neurological disorders. Its high affinity for the D2 and D3 receptor subtypes allows it to modulate dopaminergic neurotransmission, which can help alleviate symptoms associated with these conditions.
Used in Research Applications:
(+)-(1S)-1,2,3,4-tetrahydro-1-benzyl-6,7-dimethoxyquinoline hydrochloride is used as a research tool for studying dopaminergic neurotransmission and related pathways. Its potent agonist activity at the D2 and D3 receptor subtypes makes it a valuable compound for investigating the role of dopamine in various physiological and pathological processes.

Upstream product

• 20226-05-5 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisochinoline hydrochloride 

Relevant academic research and scientific papers

Half-quantity resolution method of racemic mixture of tetrahydroisoquinoline type compound

The invention discloses a half-quantity resolution method of a racemic mixture of a tetrahydroisoquinoline type compound. The half-quantity resolution method comprises the following steps: dissolving hydrochloride of the tetrahydroisoquinoline type compound into water and alkalifying under an alkaline condition to obtain the racemic mixture; dissolving the racemic mixture into a polar solvent; under a heating condition, enabling the racemic mixture to react with a single half-quantity resolution agent N-acyl-D-amino acid or D-diphenylacyl tartaric acid, so as to form salt; or after enabling the racemic mixture to react with the resolution agent N-acyl-D-amino acid for a period of time, adding the other resolution agent D-diphenylacyl tartaric acid and reacting to form the salt; after reacting, slowly cooling and crystalizing and carrying out a post-treatment process, so as to directly obtain R configuration tetrahydroisoquinoline type compound salt with high optical purity. According to the half-quantity resolution method, the half quantity of the mixed resolution agent or the half quantity of the single resolution agent is utilized, so that the dosage of the resolution agent is saved; recrystallization is not needed and a design is reasonable; the preparation method is simple and convenient and has high practicability; the total yield of an R configuration product can reach 83.25 percent at maximum and the purity can reach 97 percent or more at maximum.